PATHOMORPHOLOGICAL AND MORPHOMETRIC CHARACTERISTICS OF ALVEOLAR STRUCTURAL CHANGES IN PNEUMOPATHIES
DOI:
https://doi.org/10.55640/Keywords:
pneumopathies, alveoli, lung pathology, pathomorphology, morphometry, interalveolar septaAbstract
Pneumopathies represent a heterogeneous group of lung diseases characterized by inflammatory, degenerative, and fibrotic changes affecting the pulmonary parenchyma. The alveolar structures are among the most vulnerable components of the lung tissue, and their damage plays a key role in the development of respiratory dysfunction. This study aims to analyze the pathomorphological and morphometric alterations of alveolar structures in various pneumopathies. Special attention is given to changes in alveolar walls, air spaces, interalveolar septa, and cellular composition, as well as their quantitative morphometric characteristics. Understanding these alterations contributes to improved diagnosis, assessment of disease severity, and evaluation of pathological progression.
References
1.Katzenstein A.L.A. Diagnostic Atlas of Non-Neoplastic Lung Disease: A Practical Guide for Surgical Pathologists. 2nd ed. Philadelphia: Saunders Elsevier; 2010.
2.Hasleton P.S. Spencer’s Pathology of the Lung. 6th ed. Cambridge: Cambridge University Press; 2013.
3.Kumar V., Abbas A.K., Aster J.C. Robbins and Cotran Pathologic Basis of Disease. 10th ed. Philadelphia: Elsevier; 2021.
4.Weibel E.R. What makes a good lung? Swiss Medical Weekly. 2009;139(27–28):375–386.
5.Thurlbeck W.M. Postnatal human lung growth. Thorax. 1982;37(8):564–571.
6.Hsia C.C.W., Hyde D.M., Weibel E.R. Lung structure and the intrinsic challenges of gas exchange. Comprehensive Physiology. 2016;6(2):827–895.
7.Raghu G., Remy-Jardin M., Myers J.L., et al. Diagnosis of idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine. 2018;198(5):e44–e68.
8.Wilson M.S., Wynn T.A. Pulmonary fibrosis: Pathogenesis, etiology and regulation. Mucosal Immunology. 2009;2(2):103–121.
9.Crapo J.D., Barry B.E., Gehr P., Bachofen M., Weibel E.R. Cell number and cell characteristics of the normal human lung. American Review of Respiratory Disease. 1982;126(2):332–337.
10.Madurga A., Golec A., Pozarska A., et al. The role of alveolar epithelial cells in lung injury and repair. Cells. 2021;10(3):569.
11.Hunninghake G.W., Zimmerman M.B., Schwartz D.A., et al. Utility of morphometric analysis in diffuse lung disease. American Journal of Respiratory and Critical Care Medicine. 2001;164(2):193–200.
12.Rock J.R., Hogan B.L.M. Epithelial progenitor cells in lung development, maintenance, repair, and disease. Annual Review of Cell and Developmental Biology. 2011;27:493–512.
13.Meyer K.C. Diagnosis and management of interstitial lung disease. Translational Respiratory Medicine. 2014;2:4.
14.Myers J.L., Katzenstein A.L.A. Ultrastructural changes in alveolar injury. Human Pathology. 1988;19(9):1070–1078.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
