THE ROLE OF INFLAMMATORY MARKERS IN THE EARLY DIAGNOSIS OF SEPSIS

Authors

  • Jamolira Bobbilarat Amuja x

DOI:

https://doi.org/10.55640/

Keywords:

Sepsis, Procalcitonin, CRP, Interleukin-6, Inflammatory biomarkers, Early diagnosis

Abstract

 Sepsis is a life-threatening condition resulting from the body's extreme response to infection. Early diagnosis is crucial to reduce morbidity and mortality. Inflammatory markers, such as C-reactive protein (CRP), procalcitonin (PCT), and interleukins, play a vital role in the early identification and management of sepsis. This study investigates the diagnostic value of these biomarkers in patients with suspected sepsis in intensive care units (ICUs).

References

1.Angus, D. C., & van der Poll, T. (2013). Severe sepsis and septic shock. New England Journal of Medicine, 369(9), 840–851. https://doi.org/10.1056/NEJMra1208623

2.Becker, K. L., Nylen, E. S., White, J. C., Müller, B., & Snider, R. H. (2004). Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. Journal of Clinical Endocrinology & Metabolism, 89(4), 1512–1525.

3.Pierrakos, C., & Vincent, J. L. (2010). Sepsis biomarkers: a review. Critical Care, 14(1), R15. https://doi.org/10.1186/cc8872

4.Wacker, C., Prkno, A., Brunkhorst, F. M., & Schlattmann, P. (2013). Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. The Lancet Infectious Diseases, 13(5), 426–435.

5.Tan, M., Lu, Y., Jiang, H., & Zhang, L. (2014). The diagnostic accuracy of procalcitonin and C-reactive protein for sepsis: A systematic review and meta-analysis. Journal of Cellular Biochemistry, 115(5), 982–986.

6.Schuetz, P., Albrich, W., & Mueller, B. (2011). Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future. BMC Medicine, 9, 107. https://doi.org/10.1186/1741-7015-9-107

7.Gogos, C. A., Drosou, E., Bassaris, H. P., & Skoutelis, A. (2000). Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. Journal of Infectious Diseases, 181(1), 176–180.

8.Meisner, M. (2014). Update on procalcitonin measurements. Annals of Laboratory Medicine, 34(4), 263–273.

9.Póvoa, P. (2002). C-reactive protein: a valuable marker of sepsis. Intensive Care Medicine, 28(3), 235–243.

10.Dellinger, R. P., Levy, M. M., Rhodes, A., et al. (2013). Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Medicine, 39(2), 165–228.

Downloads

Published

2026-02-16

How to Cite

THE ROLE OF INFLAMMATORY MARKERS IN THE EARLY DIAGNOSIS OF SEPSIS. (2026). International Journal of Political Sciences and Economics, 5(02), 316-317. https://doi.org/10.55640/

Similar Articles

1-10 of 71

You may also start an advanced similarity search for this article.