A CASE REPORT OF CUSHING SYNDROME IN A CHILD INDUCED BY TOPICAL CLOBETASOL APPLICATION
Article Sidebar
Main Article Content
Abstract
Chronic low-dose steroid therapy in children can result in dysfunction of hypothalamic-pituitary-adrenal axis. However, the development of Cushing syndrome from topical steroid therapy is unusual. Long-term topical Clobetasol propionate application resulting in Cushing syndrome in a 7-month old male was evaluated. The patient was found to have severe adrenal suppression. Limiting the use of steroid-containing drugs, prescription of less potent topical agents, especially during infancy, and warning of parents about potential side effects are very important.
Downloads
Article Details
Section
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
How to Cite
References
1.Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J, editors. Harrison’s Principles of Internal Medicine. 21st ed. New York: McGraw-Hill Education; 2022. Chapter 404, Disorders of the Adrenal Cortex.
2. Zeynep Şiklar, İlknur Bostanci , Özlem Atli, Yıldız Dallar. An Infantile Cushing Syndrome Due to Misuse of Topical Steroid. Pediatric Dermatology 2004; 21 (5): 561–563.3. P.S. Tang, L.C.K Low. Childhood Cushing Syndrome due to topical clobetasol Propionate. Journal of the Hong Kong Medical Association 1989, Vol 41, No. 3, 275-76
4. W.K Woo and K.E. McKema. Iatrogenic adrenal gland suppression from use of a potent topical steroid. Clinical and Experimental Dermatology 28, 666-680
5. Gen Ramazon, Akbay Esen, Sezer Kerem. Cushing syndrome caused by topical corticosteroid: A case report. American Journal of the medical Sciences 333(3): 173-174, March 2007
6. Agwu JC, Spoudeas H, Hindmarsh PC, Pringle PJ, Brook CG. Tests of adrenal insufficiency. Arch Dis Child 1999; 80: 330–333.
7. Perry RJ, Findlay CA, MDC Donaldson. Cushing’s syndrome, growth impairment and occult adrenal suppression associated with intranasal steroid. Arch Dis Child 2002; 45:87-88.
8. CA Findlay, JF Macdonald, AM Wallace, N Geddes, and M D C Donaldson. Childhood Cushing’s syndrome induced by betamethasone nose drops, and repeat prescriptions. BMJ. 1998 September 12; 317(7160): 739–740
9. Juan Pablo Castanedo, Rosa Hilda Lopez, Benjamin Moncada. Cushing syndrome following the prescription of antifungal, antibiotic steroid cream. International Journal of Dermatology 2003, 42:318-322
10. E M Abma, R Blanken, LJM de Heide. Cushing’s syndrome caused by topical steroid therapy for psoriasis. The Netherlands Journal of Medicine April 2002 vol 60 no. 3: 148-150