DIAGNOSTIC IMPORTANCE OF ATRIAL NATRIURETIC PEPTIDE IN CARDIOVASCULAR DISEASES
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Abstract
Atrial natriuretic peptide (ANP) is a cardiac-derived hormone primarily synthesized and secreted by atrial cardiomyocytes in response to atrial stretch and volume overload. It plays a pivotal role in cardiovascular homeostasis through its natriuretic, diuretic, vasodilatory, and neurohormonal modulating effects. Over the past decades, ANP has gained increasing attention as a diagnostic and prognostic biomarker in various cardiovascular diseases, particularly heart failure, atrial fibrillation, and valvular heart disease. This article provides an in-depth overview of the molecular mechanisms of ANP action, its physiological and pathophysiological roles, and its diagnostic relevance in contemporary cardiovascular medicine.
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References
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