EARLY-LIFE IMMUNE PROGRAMMING AND THE DEVELOPMENT OF PEDIATRIC ALLERGIC DISEASES: PATHOGENETIC MECHANISMS, CLINICAL CORRELATIONS AND PREVENTIVE STRATEGIES
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Abstract
Background: Pediatric allergic diseases represent one of the fastest growing chronic conditions worldwide. The first 1,000 days of life constitute a critical window for immune programming, during which genetic, microbial, nutritional and environmental factors interact to shape long-term immune responses.
Objective: To provide a comprehensive analysis of early-life determinants of allergic diseases in children and to synthesize current mechanistic and clinical evidence relevant for pediatric practice.
Methods: Analytical review of contemporary pediatric immunology, epidemiological studies and clinical data. Pathophysiological mechanisms were examined in relation to perinatal exposures, microbiome development, epithelial barrier function and environmental triggers.
Results: Persistent Th2 polarization, impaired regulatory T-cell maturation, microbiome dysbiosis, epithelial barrier dysfunction and environmental inflammation are central mechanisms in pediatric allergy development. Cesarean section, formula feeding, early antibiotic exposure and air pollution significantly increase allergic risk.
Conclusion: Pediatric allergic diseases originate from early immune dysregulation influenced by modifiable perinatal and environmental factors. Preventive strategies should focus on immune tolerance induction during infancy.
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