BACTERIOPHAGES AND THEIR ROLE IN DETERMINING BACTERIAL SUSCEPTIBILITY
DOI:
https://doi.org/10.55640/Keywords:
bacteriophages, bacterial susceptibility, phage therapy, antibiotic resistance, microbial infections, host-pathogen interaction.Abstract
Bacteriophages, viruses that specifically infect bacteria, play a critical role in microbiology, particularly in determining bacterial susceptibility to antimicrobial agents. By attaching to bacterial surfaces and injecting their genetic material, bacteriophages can lyse bacterial cells or alter their physiology, providing a natural mechanism for controlling bacterial populations. Phage susceptibility testing has emerged as a valuable tool for identifying effective bacteriophages against pathogenic strains, informing phage therapy, and guiding antibiotic selection. Understanding the interactions between bacteriophages and bacteria is crucial for developing alternative treatments for antibiotic-resistant infections and advancing precision medicine in infectious disease management [1,2].
References
1.Twort F. An investigation on the nature of ultra-microscopic viruses. Lancet. 1915;186:1241–1243.
2.d’Hérelle F. The Bacteriophage and Its Behavior. Williams & Wilkins; 1921.
3.Abedon S.T., Kuhl S.J., Blasdel B.G., Kutter E.M. Phage treatment of human infections. Bacteriophage. 2011;1(2):66–85.
4.Loc-Carrillo C., Abedon S.T. Pros and cons of phage therapy. Bacteriophage. 2011;1(2):111–114.
5.Chan B.K., Abedon S.T., Loc-Carrillo C. Phage cocktails and the future of phage therapy. Future Microbiol. 2013;8(6):769–783.
6.Sulakvelidze A., Alavidze Z., Morris J.G. Bacteriophage therapy. Antimicrob Agents Chemother. 2001;45(3):649–659.
7.Kutter E., De Vos D., Gvasalia G., Alavidze Z., Gogokhia L., Kuhl S., Abedon S.T. Phage therapy in clinical practice: treatment of human infections. Curr Pharm Biotechnol. 2010;11:69–86.
8.Pires D.P., Cleto S., Sillankorva S., Azeredo J., Lu T.K. Genetically engineered phages: a review of advances over the last decade. Microbiol Mol Biol Rev. 2016;80(3):523–543.
9.Hyman P., Abedon S.T. Bacteriophage host range and bacterial resistance. Adv Appl Microbiol. 2010;70:217–248.
10.Kędrak-Jabłońska M., Owczarek B., Górski A. Bacteriophages in the treatment of infections: current status and perspectives. Postepy Hig Med Dosw. 2015;69:1489–1504.
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

