CHANGES IN PARIETAL CELLS IN PEPTIC ULCER DISEASE OF THE STOMACH
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Abstract
Peptic ulcer disease (PUD) is a common gastrointestinal disorder characterized by the formation of ulcers in the gastric or duodenal mucosa. Parietal cells, located in the gastric glands, play a crucial role in maintaining gastric acidity through the secretion of hydrochloric acid and intrinsic factor. Alterations in parietal cell structure and function are often observed in patients with PUD and contribute to the pathogenesis and progression of the disease. These changes may include cellular degeneration, decreased acid secretion, hyperplasia, or morphological abnormalities induced by Helicobacter pylori infection, chronic inflammation, or exposure to nonsteroidal anti-inflammatory drugs (NSAIDs). Understanding the cellular and molecular changes in parietal cells provides insight into disease mechanisms and may guide therapeutic strategies aimed at restoring normal gastric function and promoting mucosal healing.
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