SERUM CREATININE AND BLOOD UREA NITROGEN LEVELS IN PATIENTS WITH CHRONIC RENAL FAILURE: A CASE–CONTROL STUDY
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Abstract
The consequences of chronic kidney disease (CKD) are manifested in progressive impaired kidney functioning and worsening of the ability to get rid of nitrogenous waste products. Objective: The purpose of the study was not only to determine the amount of serum creatinine and blood urea nitrogen (BUN) of the patients with chronic renal failure, but also to compare the results of the study with normal values. Methods: It was a cross-sectional study where 30 healthy controls and 60 participants who had long-term renal failure were investigated. An automated analyzer (chemical) was used to determine the creatinine and BUN levels of the serum. Results: Serum creatinine and BUN levels were substantially higher in the chronic renal failure group than in the control group (p < 0.05) for both genders and age groups. Conclusion: Biochemical evidence of kidney failure is the appropriate use of serum creatinine and BUN, which can also be effective in determining the magnitude of chronic renal failure.
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References
1.Lancet Editorial. Chronic kidney disease. Lancet. 2025; 395(10230):1942–55.
2.Stevens PE, Levin A. Evaluation and management of chronic kidney disease. Ann Intern Med. 2021; 174(3):456–67.
3.Levey AS, Inker LA. Assessment of glomerular filtration rate. N Engl J Med. 2020; 382(17):1655–66.
4.Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function. Clin Chem. 1992; 38(10):1933–53.
5.Silva FG. Blood urea nitrogen as a renal function marker. Clin Chim Acta. 2022; 529:1–7.
6.Waikar SS, Bonventre JV. Biomarkers for kidney disease. J Am Soc Nephrol. 2023; 34(1):123–35.
7.Vaidya VS, Ferguson MA, Bonventre JV. Biomarkers in acute and chronic kidney disease. Annu Rev Pharmacol Toxicol. 2021; 61:249–72.
8.KDIGO 2024 CKD Guideline. Kidney Int. 2024; 106(Suppl 1):1–150.
9.Xie Y, Bowe B, Mokdad AH, et al. Analysis of CKD trends. Lancet Planet Health. 2022; 6(9):e794–806.
10.GBD Chronic Kidney Disease Collaboration. Global burden of CKD. Lancet. 2023; 401(10392):983–1002.