MODERN THERAPEUTIC APPROACHES TO UNSTABLE ANGINA
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Abstract
Unstable angina (UA) represents a critical phase of ischemic heart disease, necessitating rapid risk stratification and intervention to prevent myocardial infarction. This article presents a prospective clinical study conducted at the Department of Faculty Therapy of Andijan State Medical Institute. Utilizing the IMRAD framework, the research evaluates the efficacy of an "Early Invasive Strategy" (coronary angiography within 24 hours) compared to an "Optimized Conservative Strategy" (medical therapy with selective angiography) in 120 high-risk UA patients. The study also integrates a novel assessment of metabolic and neurohumoral markers. Results indicate that the early invasive approach significantly reduces the incidence of Major Adverse Cardiovascular Events (MACE) at 6 months (15 percent vs. 32 percent). Furthermore, the study highlights the importance of correcting lipid peroxidation and sympathetic overactivity as adjunct therapeutic targets. The authors conclude that while revascularization is crucial, long-term prognosis depends on a holistic approach combining interventional cardiology with targeted metabolic therapy.
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