ANTIOXIDANT CORRECTION OF GASTRIC MUCOSAL MORPHOLOGICAL ALTERATIONS IN BACKGROUND CHEMICAL INJURY USING THE PHYTOGENIC AGENT GULIMSAR
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Abstract
Background: Oxidative stress represents a pivotal pathogenetic mechanism underlying gastric mucosal injury induced by chemical and toxic agents. Excessive generation of reactive oxygen species (ROS) disrupts epithelial integrity, impairs microcirculation, and triggers inflammatory cascades, ultimately compromising mucosal regeneration.
Objective: To investigate morphological and morphometric alterations of the gastric mucosa under background chemical injury and to evaluate the efficacy of antioxidant correction using the phytogenic preparation Gulimsar.
Methods: An experimental study was conducted on laboratory animals with chemically induced subnecrotic gastric mucosal damage. Histological, morphometric, and biochemical analyses were performed, including assessment of malondialdehyde (MDA), superoxide dismutase (SOD), and catalase activity.
Results: Chemical injury resulted in epithelial desquamation, glandular disorganization, vascular congestion, and pronounced inflammatory infiltration accompanied by elevated MDA levels and reduced antioxidant enzyme activity. Administration of Gulimsar significantly decreased lipid peroxidation markers, restored enzymatic antioxidant defenses, reduced inflammatory infiltration, and promoted structural regeneration of gastric glands.
Conclusion: Antioxidant correction using Gulimsar demonstrates pronounced cytoprotective and reparative effects on chemically injured gastric mucosa through modulation of oxidative stress and restoration of tissue homeostasis.
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